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The self-association of caffeine in solution, driven by the hydrophobic effect, is a simple example of molecular aggregation. It obeys an isodesmic association model in which each successive binding occurs with the same equilibrium constant. Here, we describe an activity for chemistry students that explores this phenomenon using nuclear magnetic resonance (NMR) spectroscopy. By analyzing concentration-dependent chemical shift changes in the 1H NMR spectra of caffeine dissolved in D2O, students are introduced to uses of NMR spectroscopy beyond structure elucidation. They gain hands-on experience in quantifying supramolecular equilibria and consider their results in the context of molecular-level interactions. 

Context: Scholars in the software engineering (SE) research community have investigated career advancement in the software industry. Research topics have included how individual and external factors can impact career mobility of software professionals, and how gender affects career advancement. However, the community has yet to look at career mobility from the lens of accessibility. Specifically, there is a pressing need to illuminate the factors that hinder the career mobility of blind and low vision software professionals (BLVSPs). Objective: This study aims to understand aspects of the workplace that impact career mobility for BLVSPs. Methods: We interviewed 26 BLVSPs with different roles, years of experience, and industry sectors. Thematic analysis was used to identify common factors related to career mobility. Results: We found four factors that impacted the career mobility of BLVSPs: (1) technical challenges, (2) colleagues’ perceptions of BLVSPs, (3) BLVSPs’ own perceptions on managerial progression, and (4) BLVSPs’ investment in accessibility at the workplace. Conclusion: We suggest implications for tool designers, organizations, and researchers towards fostering more accessible workplaces to support the career mobility of BLVSPs.